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Objetivos Objetivos

Objetivo 1

Valorar la eficacia antiarrítmica de DECA­11, empagliflozina, y dapagliflozina en modelos murinos y porcinos de IC con fracción de eyección reducida (ICFEr) y en un modelo murino de IC con fracción de eyección preservada (ICFEp)

Objetivo 2

Identificar el mecanismo y los determinantes moleculares responsables del efecto de DECA­11, empagliflozina, y dapagliflozina sobre la INa y la IK1

Objetivo 3

Identificar el motivo mínimo responsable del efecto de DECA­11 y funcionalizarlo para su administración por vía sistémica.

Project Completed

66800+
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