R Caballero, S Pérez-Martín, J Rapún, G San José, L Loya, A Cámara-Checa, T Crespo-García, J A Bernal, J Tamargo, F M Cruz, B Lopez, D Filgueiras-Rama, A González, J Jalife, E Delpón, DECA11 selectively increases human INa and IK1 and is antiarrhythmic in a mouse model of heart failure, European Heart Journal, Volume 46, Issue Supplement_1, November 2025, ehaf784.4644, https://doi.org/10.1093/eurheartj/ehaf784.4644
Fernandes VS, Caballero R, Siguero-Álvarez M, Papoutsi T, Gimeno-Blanes JR, Delpón E, de la Pompa JL. Cardiac electrical abnormalities in a mouse model of left ventricular non-compaction cardiomyopathy. PLoS One. 2025 May 7;20(5):e0314840. doi: 10.1371/journal.pone.0314840. PMID: 40334239; PMCID: PMC12058163.
Cámara-Checa A, Álvarez M, Rapún J, Pérez-Martín S, Núñez-Fernández R, Rubio-Alarcón M, Crespo-García T, Desviat LR, Delpón E, Caballero R, Richard E. Propionic Acidemia-Induced Proarrhythmic Electrophysiological Alterations in Human iPSC-Derived Cardiomyocytes. J Inherit Metab Dis. 2025 May;48(3):e70030. doi: 10.1002/jimd.70030. PMID: 40302352; PMCID: PMC12041839.
Delpón E, Caballero R, Tamargo J. News in cardiovascular pharmacotherapy from the ACC.25 Meeting. Eur Heart J Cardiovasc Pharmacother. 2025 Jul 7;11(4):393-396. doi: 10.1093/ehjcvp/pvaf029. PMID: 40300823; PMCID: PMC12231124.
Rapún J, Pérez-Martín S, Cámara-Checa A, San José G, Núñez-Fernández R, Crespo-García T, Hoban A, Rubio-Alarcón M, Martínez-Blanco E, Tamargo J, Díez-Guerra FJ, López B, Gómez R, González A, Delpón E, Caballero R. Two concurrent mechanisms are responsible for the I<sub>Na</sub> increase produced by dapagliflozin and empagliflozin in healthy and heart failure cardiomyocytes. Biomed Pharmacother. 2025 May;186:117984. doi: 10.1016/j.biopha.2025.117984. Epub 2025 Mar 17. PMID: 40101587.
Couselo-Seijas M, Vázquez-Abuín X, Gómez-Lázaro M, Pereira L, Gómez AM, Caballero R, Delpón E, Bravo S, González-Juanatey JR, Eiras S. FABP4 Enhances Lipidic and Fibrotic Cardiac Structural and Ca<sup>2+</sup> Dynamic Changes. Circ Arrhythm Electrophysiol. 2024 Sep;17(9):e012683. doi: 10.1161/CIRCEP.123.012683. Epub 2024 Aug 30. PMID: 39212041.
Esteban-Arderíus, C. Cuadros-Higueras, D. Núñez-Villanueva. Synthetic approaches to heterocyclic α,α-disubstituted amino acids. Targets Heterocycl. Syst. 2024. 139-158. Italian Chemical Society. CL. DOI: http://dx.medra.org/10.17374/targets.2025.28.139.
Caballero R, Delpón E, Tamargo J. News in cardiovascular pharmacotherapy from the ACC.24 Meeting. Eur Heart J Cardiovasc Pharmacother. 2024 Jul 16;10(4):272-277. doi: 10.1093/ehjcvp/pvae034. PMID: 38907602.
Gallego-Delgado M, Cámara-Checa A, Rubio-Alarcón M, Heredero-Jung D, de la Fuente-Blanco L, Rapún J, Plata-Izquierdo B, Pérez-Martín S, Cebrián J, Moreno de Redrojo L, García-Berrocal B, Delpón E, Sánchez PL, Villacorta E, Caballero R. Variable Penetrance and Expressivity of a Rare Pore Loss-of-Function Mutation (p.L889V) of Nav1.5 Channels in Three Spanish Families. Int J Mol Sci. 2024 Apr 25;25(9):4686. doi: 10.3390/ijms25094686. PMID: 38731905; PMCID: PMC11083067
Cámara-Checa A, Rubio-Alarcón M, Dago M, Crespo-García T, Rapún J, Marín M, Tamargo J, Gómez R, Caballero R, Delpón E. Reply to Benndorff and DiFrancesco: Reliable human HCN4 single-channel recordings using the cell-attached configuration in expression systems. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2402992121. doi: 10.1073/pnas.2402992121. Epub 2024 Apr 8. PMID: 38588416; PMCID: PMC11032473.
Fraile A, Cebrián J, Thuissard-Vasallo I, Pérez-Martín S, Casado R, Gil-Fournier B, Alonso-Martín J, Tamargo J, Caballero R, Delpón E, Cosío FG. Coexistent HCN4 and GATA5 Rare Variants and Atrial Fibrillation in a Large Spanish Family. Can J Cardiol. 2024 Jul;40(7):1270-1280. doi: 10.1016/j.cjca.2024.02.024. Epub 2024 Mar 1. PMID: 38432398.
Tamargo J, Villacastín J, Caballero R, Delpón E. Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect. Pharmacol Res. 2024 Feb;200:107077. doi: 10.1016/j.phrs.2024.107077. Epub 2024 Jan 19. PMID: 38244650.
Cámara-Checa A, Perin F, Rubio-Alarcón M, Dago M, Crespo-García T, Rapún J, Marín M, Cebrián J, Gómez R, Bermúdez-Jiménez F, Monserrat L, Tamargo J, Caballero R, Jiménez-Jáimez J, Delpón E. A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2305135120. doi: 10.1073/pnas.2305135120. Epub 2023 Nov 30. PMID: 38032931; PMCID: PMC10710060.
Redondo-Rodríguez Amndres et al. J Am Heart Assoc. 2024;13:e038441. DOI: 10.1161/JAHA.124.038441
Martínez-Val Ana et al. Anal. Chem. 2025;97(36):19730-19741. DOI: 10.1021/acs.analchem.5c03294
Mondéjar-Parreño G, Sánchez-Pérez P, Cruz FM, Jalife J. Promising tools for future drug discovery and development in antiarrhythmic therapy. Pharmacol Rev. 2025 Jan;77(1):100013. doi: 10.1124/pharmrev.124.001297. Epub 2024 Nov 22. PMID: 39952687.
Mondéjar-Parreño G, Moreno-Manuel AI, Ruiz-Robles JM, Jalife J. Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome. Cell Discov. 2025 Jan 10;11(1):3. doi: 10.1038/s41421-024-00738-0. PMID: 39788950; PMCID: PMC11717978.
Cruz FM, Moreno-Manuel AI, Pérez PS, Ruiz-Robles JM, Socuellamos PG, Gutiérrez LK, Vera-Pedrosa ML, Gutierrez AT, Mondéjar Parreño G, Macías Á, Martínez-Carrascoso I, Bermúdez-Jiménez FJ, Arias Santiago S, Martínez de Benito F, Braza-Boils A, Valenzuela C, Morillo CA, Zorio E, Jiménez-Jaimez J, Jalife J. Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome. medRxiv [Preprint]. 2024 Dec 11:2024.12.10.24318629. doi: 10.1101/2024.12.10.24318629. PMID: 39711719; PMCID: PMC11661358.
Contribuciones a congresos
XVIII Iberian Peptide Meeting. Lisboa, 27-29/11/2023. Póster: Difficult Sequence” Cardiovascular Peptide. Optimizing Synthesis and Purification. Carlos Cuadros-Higueras, Pablo Esteban-Arderíus, M. Jesús Pérez de Vega, Diego Núñez-Villanueva, Ricardo Caballero, Eva Delpón, Rosario González-Muñiz.
37th European Peptide Symposium. Florence, Italy. 26-28/08/2024. Poster: Preliminary Medicinal Chemistry Program on a new cardiovascular peptide. Carlos Cuadros-Higueras, Pablo Esteban-Arderíus, Sara Pérez-Martín, M. Jesús Pérez de Vega, Ricardo Caballero, Eva Delpón, Diego Núñez-Villanueva, Rosario González-Muñiz.
VI QuimBioQuim. Jaén, 23/10/2024. Póster: Synthesis, permeability and stability of new cardiovascular peptides. Carlos Cuadros-Higueras, Pablo Esteban-Arderíus, Enora Trubuil, Sara Pérez-Martín, M. Jesús Pérez de Vega, Ricardo Caballero, Eva Delpón, Diego Núñez-Villanueva, Rosario González-Muñiz.
Iberian Peptide Meeting. Santiago de Compostela, 26-28/02/2025. Short Talk: Advances in cardiovascular DECA-11 Peptide analogues”. Carlos Cuadros-Higueras, Pablo Esteban-Arderíus, Enora Trubuil, Sara Pérez-Martín, M. Jesús Pérez de Vega, Ricardo Caballero, Eva Delpón, Diego Núñez-Villanueva, Rosario González-Muñiz